Amiflamine is an unregulated #phenylethylamine / #amphetamine derivative that seemed to have some light research in the 80's. It is a reversible MAO-A inhibitor. It also shows evidence that it is a #catecholaminereleasing agent.
The rodent model displayed a preference to MAOI in the serotonergic neurons. The primate model used cerebral spinal fluid (CSF) markers to suggest the compound acts equally on #serotonin #norepinephrineand #dopamine metabolism. However, the same primate study showed a preference to serotonin and dopamine at lower doses. There were minimal amounts of Amiflamine and larger amounts of two bioactive metabolites found in CSF after 3-6 hours.
There was actually a human study run with 9 inpatients. This obviously did not provide any statistically significant conclusions. However, I will note that the patients did receive 2.5-5mgs twice per day for three weeks. The most noted side effects were trouble sleeping and headaches. .